Believe it or not, opossums get a bad rap most of the time and generally do not cause problems. They generally take advantage of preexisting structural problems or previous damage caused by other, more destructive, animals.
The biggest issue National Wildlife Control, LLC has experienced with opossums are that they often die in hidden areas such as under decks or porches. Exclusion is often the best method for dealing with these critters.
Manufactured homes are most at risk for an intrusion from an opossum because of their insulation layer under the floor. Opossums take advantage of the insulation and often will den under the floor. We have personally witnessed opossums in these situation come from under bath tubs and out of sink bases.
Make sure to be on the lookout for opossum on your property if you notice the following: